Korean skin care is gaining attention for innovative and effective ingredients, notably polydeoxyribonucleotide (PDRN), which is derived from salmon sperm. This unique anti-aging component has become increasingly popular, particularly in serums like the Iope PDRN Caffeine Shot, according to Dr. Gretchen Frieling, a board-certified dermatopathologist and founder of a skin care brand. PDRN is recognized for its ability to accelerate skin repair, promote new tissue growth, enhance hydration, and reduce hyperpigmentation.
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The surge in products containing PDRN has led to several options available over the counter, all of which have attracted interest. The Iope PDRN Caffeine serum, suggested by Beverly Hills plastic surgeon Dr. Daniel Gould, is among the most favored. This serum includes niacinamide, which brightens the skin, and probiotics known for maintaining skin health. Caffeine in the formula may help reduce sun damage wrinkles.
Medicube, a prominent Korean beauty brand, offers a PDRN peptide serum that combines salmon sperm-derived PDRN with five types of peptides, known to bolster collagen production and skin texture. The serum also includes soothing basil leaf extract and niacinamide for hydration and dark spot fading.
Another distinctive product from Medicube is a moisturizer featuring cream capsules of salmon-derived PDRN mixed in a jelly base. This allows users to customize their application based on the number of capsules used, complemented by collagen and hyaluronic acid for optimal moisture retention and a radiant complexion.
Experts Gould, Spearman, and Frieling also recommend the VT Cosmetics PDRN 100 Essence, which contains 10% PDRN from wild Korean ginseng. This essence aims for maximum skin absorption and includes panthenol and ceramides to support skin health.
For a more affordable alternative to in-office microneedling, the VT Cosmetics PDRN Reedle Shot claims to enhance skin texture and absorption through a micro-needling mechanism. The Kahi multi-balm stick is another versatile option containing salmon-derived collagen to nourish various areas of the skin.
Other notable products involve the Genabelle PDRN Vita Toning ampoule for antioxidant protection and skin brightening effects, and the Rejuran Turnover ampoule, recognized as a leading PDRN product in the market. Mediheal's sheet masks utilize rose-derived PDRN, touted for improving skin radiance and hydration.
Overall, PDRN contributes to anti-aging benefits by stimulating collagen and elastin production, which can reduce fine lines and sagging, as noted by experts. It is available in both injectable and topical forms, broadening its appeal in cosmetic skincare. Vegan alternatives from plants like wild ginseng are being explored, although they differ at a molecular level from the original salmon-derived PDRN.