The Cosmetic Ingredient Review (CIR) Expert Panel for cosmetic ingredient safety conducted its 177th meeting on October 5-6. The next meeting is scheduled for December 7-8 at The Darcy Hotel in Washington, DC, with a submission deadline of October 30, 2026, for contributions.

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During the recent meeting, the panel issued the following findings:

**Final Safety Assessments**

- 2-Bromo-2-Nitropropane-1,3-Diol: Safe when formulated to be non-sensitizing.

- Alkyl Gallates: Safe when formulated to be non-irritating/non-sensitizing (four ingredients).

- Pyrogallol: Insufficient data on safety.

- Polyacrylate-13: Safe.

**Tentative Safety Assessments**

- Kojic Acid: Split conclusion—insufficient data for anogenital wipes, douches, and baby products; safe for other uses.

- Phthalates: Split conclusion—insufficient data for two ingredients; safe for one.

- Oxyquinoline & Oxyquinoline Sulfate: Split conclusion—one ingredient is safe as a hydrogen peroxide stabilizer; both ingredients have insufficient data for other uses.

- Phosphine Oxides: Safe as used in nail products; insufficient data for non-nail applications.

- Ethyl Tafluprostamide & Isopropyl Cloprostenate: Insufficient data.

- Willow-derived ingredients: Split conclusion—one ingredient safe in non-baby products; insufficient data for the baby product uses of that ingredient and all other uses of five additional ingredients.

**Insufficient Data Announcements**

- Sigesbeckia Orientalis Extract: Insufficient data for one ingredient.

- Sodium Hyaluronate Crosspolymers: Insufficient data for six ingredients.

- Sodium Hydrosulfite: Insufficient data for one ingredient.

- Tosylamide/Formaldehyde Resin & Tosylamide/Epoxy Resin: Insufficient data for two ingredients.